Knowledge about different stress responses during different stress phases from the biopsychosocial perspective is very useful for helpers. Different stress responses in different stress phases indicate the need for different interventions. In the pre-acute stress phase by applying certain steps, methods, and approaches is possible to be better prepared for the stressful event(s). Knowledge about different immediate needs and complex reactions with their neurophysiological background in acute and follow-up stress phases offers a good basis for effective interventions. The Six Cs model is a well-established neuropsychology-based model for early psychological intervention.